Current Issue
Volume 14, Issue 4: April 15 , 2008 (Next issue: May 13, 2008)
In this Issue:
- Enhancer epigenetics regulates apoptosis
- Nuclear membrane Otefin interacts with Smads
- Heterochromatin kills kinetochores
- Vps74p oligomers localize Golgi enzymes
- Transit-amplifying cells in neuroblast lineages
- Cell-autonomous branching responses to hypoxia
- Cell-cell interactions shape single-cell tube formation
- Group cell migration in branching morphogenesis
- Endodermal interactions induce pancreatic β-cells
- Notch in mouse epidermal development
- The circuitry of dorso-ventral axis formation
- CASTOR in cardiac midline differentiation
- An alternating pattern of digit formation
Featured Article
Access to the Featured Articles is free for all readers
Uncoupling Sonic Hedgehog Control of Pattern and Expansion of the Developing Limb Bud
Zhu et al.
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Zhu et al. show that Shh controls digit development in a transient early phase regulating digit identity, and an extended growth phase which allocates digit primordia in an unexpected sequence. Their results imply mechanisms by which evolution could alter digit number without perturbing digit morphology. |
Issue Highlights
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Using time-lapse imaging in cultured mammary gland epithelium, Ewald et al. show that ductal branching morphogenesis occurs via a process of cell migration and rearrangement that is distinct from previously characterized collective cell movements. |
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Drosophila embryos become resistant to γ-ray induced apoptosis at later, more differentiated stages during development. Now, Zhang et al. reveal that this resistance is due to the formation of a heterochromatin-like structure at an irradiation-responsive enhancer element upstream of pro-apoptotic genes. |
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Rasmussen et al. examine how two cells in the C. elegans pharynx become adjacent, single-cell tubes. Cells first migrate along a transient tract of laminin lining one lateral epithelial cell-cell interface. They are then distinguished by differential Notch signalling to self-fuse using distinct homotypic fusogens. See also a preview by Hardin. |
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Commentary: Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint Daniel J. Burke and P. Todd Stukenberg Meeting Review: Plant Hormones and Signaling Paula McSteen and Yunde Zhao
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Annotated Table of Contents
View the Annotated Version of the Table of Contents with contextual explanations of the articles in the issue.
Top 20 Articles
These are the Top 20 Papers by download from the Developmental Cell web site for the last 30 days. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.
Featured Topic
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A selection of recent Developmental Cell papers in the area of Cell Death/Cell Survival. For previous featured topics, click here. |
March 2008
Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye.
Yun Fan and Andreas Bergmann
PpAtg30 tags peroxisomes for turnover by selective autophagy.
Jean-Claude Farré, Ravi Manjithaya, Richard D. Mathewson, and Suresh Subramani
February 2008
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Ann Cassidy-Stone, Jerry E. Chipuk, Elena Ingerman, Cheng Song, Choong Yoo, Tomomi Kuwana, Mark J. Kurth, Jared T. Shaw, Jenny E. Hinshaw, Douglas R. Green, and Jodi Nunnari
[Summary] [Full Text]
January 2008
Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Jing Li, Cong Ran, Edward Li, Faye Gordon, Grant Comstock, Hasan Siddiqui, Whitney Cleghorn, Hui-Zi Chen, Karl Kornacker, Chang-Gong Liu, Shusil K. Pandit, Mehrbod Khanizadeh, Michael Weinstein, Gustavo Leone, and Alain de Bruin
[Summary] [Full Text]
November 2007
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.
Ato Wright, William W. Reiley, Mikyoung Chang, Wei Jin, Andrew Joon Lee, Minying Zhang, and Shao-Cong Sun
September 2007
Tumor Suppressor CYLD Regulates JNK-Induced Cell Death in Drosophila
Lei Xue, Tatsushi Igaki, Erina Kuranaga, Hiroshi Kanda, Masayuki Miura, and Tian Xu
[Summary] [Full Text]
And from Trends journals:
Trends in Cell Biology, April 2008
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Jerry E. Chipuk and Douglas R. Green
Mitochondria in cancer cells: what is so special about them?
Vladimir Gogvadze, Sten Orrenius and Boris Zhivotovsky
Trends in Microbiology, Available online 18 March 2008
Staying alive: bacterial inhibition of apoptosis during infection
Christina S. Faherty and Anthony T. Maurelli
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Featured Job
Postdoctoral Researchers: Developmental Biology |
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Two positions are now available to characterize the function of Hox proteins in limb development. Qualified applicants should have expertise in one or more of the following areas: protein expression, in situ hybridization, qRTPCR, immunohistochemistry, organ culture, in vitro gene expression assays, site directed mutagenesis, and chromatin immunoprecipitation. A curriculum vitae, samples of first author publications, and the names of three references should be mailed to H. Scott Stadler, Ph.D., Shriners Hospital for Children, Mail code SHC-Research, 3101 SW Sam Jackson Park Road, Portland, OR 97239 or emailed to HSS@SHCC.org. OHSU and the Shriners Hospitals for Children are EOE, Drug Free, and Smoke Free Employers. |
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