Developmental Cell

Cell Press

9 December, 2008
Volume 15, Issue 6

Volume 15, Issue 6

On the cover: Epifluoresence image of RPE-hTERT cells depleted of the BBSome subunit BBIP10. Microtubules are shown in red and the centrosomal marker pericentrin is in white. Reduced levels of acetylated tubulin are seen as rare green strands and constitute the phenotypic hallmark of BBIP10-depleted cells. The loss of acetylated microtubules is specific to the depletion of BBIP10, and microtubule acetylation remains unaffected by the depletion of other BBSome subunits. For more information, see Loktev et al., pp. 854–865.

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In the December Issue

An invasive isoform of Mena

ER stress and fatty liver disease

Kinase regulation of caspase-9 in the retina

A BBSome subunit regulates microtubule stability

Ensconsin promotes kinesin recruitment

Dynamic gene regulation by Polycomb

Rb-independent degradation of E2f1

Regulation of centrosome size

Orientating stem cell divisions in the root

Cross-regulation of organ size

Sequestration of a replication initiator

Review on Hedgehog signaling

Click here for the complete table of contents.

Immediate Early Publication

Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription

Takanori Amano, Tomoko Sagai, Hideyuki Tanabe, Yoichi Mizushina, Hiromi Nakazawa, and Toshihiko Shiroishi

Featured Article

Dyrk1A gene dosage is linked to Down Syndrome. Laguna et al. find that DYRK1A, which is a kinase, controls the organization and function of the mouse retina via phosphorylation of caspase-9.

Issue Highlights

		Rutkowski and colleagues reveal an unexpected link between ER stress and fatty liver disease, the most common liver disorder in western countries.
		Willemsen et al. show that the Arabidopsis NAC-domain transcription factors, FEZ and SOMBRERO, control the orientation of cell division in root stem cells.
		Waxman et al. provide evidence that organ size is regulated by communication between organ fields, suggesting potential new causes for syndromes affecting both heart and forelimb.
		Review Hedgehog Signaling in Development and Cancer J. Jiang and C.-c. Hui