Current Issue
Volume 15, Issue 1: August 12, 2008
(Next issue: September 16, 2008)
In this Issue:
- CP110 suppresses primary cilia formation
- PAR protein asymmetry regulates PIP2 synthesis
- Clathrin-mediated endocytosis prolongs EGFR signaling
- Receptor transphosphorylation in brassinosteroid signaling
- Six3 haploinsufficiency causes holoprosencephaly
- BMP feedback inhibition by Crossveinless-2
- MicroRNA regulation of angiogenesis (Wang et al and Fish et al)
- Maelstrom in meiotic transposon repression
- A Hox molecular switch regulates EGF secretion
- Fat signaling mediates morphogen action
- p38MAPK in tooth and palate BMP signaling
- Commentary on gene location in the nucleus
Immediate Early Publication
Global Analysis of the Meiotic Crossover Landscape
Stacy Y. Chen, Tomomi Tsubouchi, Beth Rockmill, Jay S. Sandler, Daniel R. Richards, Gerben Vader, Andreas Hochwagen, G. Shirleen Roeder, and Jennifer C. Fung
Developmental Cell
10.1016/j.devcel.2008.07.006
[Summary] [Full Text] [PDF] [Supplemental Data]
Featured Article
Access to the Featured Articles is free for all readers
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Primary cilia are nonmotile sensory organelles implicated in cellular signaling. The centrosomal protein CP110 inhibits primary cilia formation through an unknown mechanism. Tsang et al. show that CP110 interacts with CEP290, a protein deficient in human ciliary disease. CP110 antagonizes CEP290 function, which cooperates with Rab8a to promote ciliogenesis. |
Issue Highlights
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Molecular mechanisms that link organ patterning to organ growth remain mysterious. Rogulja et al. show that in the Drosophila wing, a BMP morphogen gradient controls graded expression of Fat/Hippo signaling pathway regulators. They present evidence that patterning is coupled to growth control via this mechanism. |
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Endocytosis of cell surface signaling receptors can either prolong signaling activity through recycling or attenuate it through receptor degradation. Here, Sigismund et al. show that, contrary to previous expectations, in the case of the EGFR, clathrin-mediated internalization promotes recycling and prolongs the signal duration, whereas clathrin-independent endocytosis leads to degradation. |
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Tight control of transposons is essential for the integrity of the germline. Soper et al. demonstrate that Maelstrom, a component of a germ cell-specific organelle called nuage, is indispensable for DNA methylation-controlled silencing of transposons in meiosis and for homologous chromosome synapsis in the mouse male germline. |
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In humans, mutations in genes encoding Sonic hedgehog (Shh) and the homeobox protein SIX3 cause holoprosencephaly, a common forebrain malformation characterized by incomplete separation of the cerebral hemispheres. Geng et al. reveal that Six3 proteins carrying holoprosencephaly-associated mutations have decreased activity and fail to activate Shh expression, thereby causing holoprosencephaly. |
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Commentary: The Impact of Gene Location in the Nucleus on Transcriptional Regulation Niall Dillon |
Annotated Table of Contents
View the Annotated Version of the Table of Contents with contextual explanations of the articles in the issue.
Top 20 Articles
These are the Top 20 Papers by download from the Developmental Cell web site for the last 30 days. You can see the summaries if you are registered, or full text and PDFs if you have subscribed.
Featured Topic
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A selection of recent Developmental Cell papers about RNA. For previous featured topics, click here. |
August 2008
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
S. Wang, A.B. Aurora, B.A. Johnson, X. Qi, J. McAnally, J.A. Hill, J.A. Richardson, R. Bassel-Duby, and E.N. Olson
miR-126 Regulates Angiogenic Signaling and Vascular Integrity
J.E. Fish, M.M. Santoro, S.U. Morton, S. Yu, R.-F. Yeh, J.D. Wythe, K.N. Ivey, B.G. Bruneau, D.Y.R. Stainier, and D. Srivastava
June 2008
A Link between RNA Metabolism and Silencing Affecting Arabidopsis Development
Brian D. Gregory, Ronan C. O'Malley, Ryan Lister, Mark A. Urich, Julian Tonti-Filippini, Huaming Chen, A. Harvey Millar, and Joseph R. Ecker
[Summary] [Full Text]
RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse
Kay D. Wagner, Nicole Wagner, Hossein Ghanbarian, Valérie Grandjean, Pierre Gounon, François Cuzin, and Minoo Rassoulzadegan
[Summary] [Full Text]
MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors
Jun Lu, Shangqin Guo, Benjamin L. Ebert, Hao Zhang, Xiao Peng, Jocelyn Bosco, Jennifer Pretz, Rita Schlanger, Judy Y. Wang, Raymond H. Mak, David M. Dombkowski, Frederic I. Preffer, David T. Scadden, and Todd R. Golub
A Direct Role for FMRP in Activity-Dependent Dendritic mRNA Transport Links Filopodial-Spine Morphogenesis to Fragile X Syndrome
Jason B. Dictenberg, Sharon A. Swanger, Laura N. Antar, Robert H. Singer, and Gary J. Bassell
[Summary] [Full Text]
And from Trends journals:
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Trends in Plant Science, July 2008 Special issue - "Noncoding and small RNAs: the dark matter of the cell" The July issue of Trends in Plant Science is entirely dedicated to highlighting the most recent advances on noncoding and small RNAs with a special focus on plants. |
Trends in Genetics, August 2008
RNA-binding proteins in human genetic disease
Kiven E. Lukong, Kai-wei Chang, Edouard W. Khandjian, Stéphane Richard
July 2008
MicroRNA regulation of messenger-like noncoding RNAs: a network of mutual microRNA control
Yi Zhao, Shunmin He, Changning Liu, Songwei Ru, Haitao Zhao, Zhen Yang, Pengcheng Yang, Xiongyin Yuan, Shiwei Sun, Dongbo Bu, Jiefu Huang, Geir Skogerbø, Runsheng Chen
Micromanagers of malignancy: role of microRNAs in regulating metastasis
Li Ma and Robert A. Weinberg
Trends in Cell Biology, July 2008
Lukas Stalder and Oliver Mühlemann
Trends in Immunology, July 2008
microRNAs and the immune response
Mark A. Lindsay
Trends in Biotechnology, July 2008
RNAi-mediated crop protection against insects
Daniel R.G. Price and John A. Gatehouse
Trends in Biochemical Sciences, June 2008
Viral IRES RNA structures and ribosome interactions
Jeffrey S. Kieft
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